Lewis married Nancy Crain on 10 Nov 1839 in Fleming County, Kentucky, United States. Nancy was born on 14 Dec 1811; died on 5 Feb 1865. [Group Sheet] [Family Chart]

1. Lucinda E. Markwell was born on 30 Aug 1840; died on 10 Jul 1842.
2. Jesse Markwell was born on 15 Feb 1843; and died.
3. Mary I. Markwell was born on 10 Jul 1845; died on 22 Oct 1864.
4. Sarah L. Markwell was born on 21 Jan 1848; and died.
5. Nancy E. Markwell was born on 20 Aug 1850; and died.
6. Eliza C. Markwell was born on 6 Sep 1853; and died.

Family/Spouse: Elizabeth B.. Elizabeth was born on 1 Nov 1798; died on 9 Jun 1839. [Group Sheet] [Family Chart]

1. Elias W. Markwell was born on 17 Apr 1822; and died.
2. Florinda Markwell was born on 5 Aug 1823; and died.
3. Matilda J. Markwell was born on 8 Oct 1825; and died.
4. Marion Frances Markwell was born on 5 May 1828; and died.
5. Henry D. Markwell was born on 21 Jan 1830; died on 7 Jul 1842.
6. Jasper N. Markwell was born on 24 Nov 1832; and died.
7. John M. Markwell was born on 2 Aug 1834; died on 8 Feb 1839.
8. Elizabeth A. Markwell was born on 2 Apr 1836; and died.
9. Lewis Markwell was born on 1 Jun 1839; died on 9 Sep 1839.

Lewis married Amelia Ellen Swim on 30 Jun 0018. Amelia (daughter of William S Swim and Sarah M Saunders) was born on 1 Jul 1844; died on 30 Apr 1888. [Group Sheet] [Family Chart]

1. Lewis Markwell was born on 25 Mar 1876; and died.
2. Texas Markwell was born on 23 Jul 1877; and died.
3. Gertrude C. Markwell was born on 6 Apr 1879; died in Jun 1968 in Wisconsin, United States.