Isaac married Lydia Harmon on 30 Sep 1852 in Fleming County, Kentucky, United States. Lydia (daughter of George Harmon and Elizabeth) was born about 1836 in Bath County, Kentucky, United States; and died. [Group Sheet] [Family Chart]

1. Albert R. Alfrey was born on 12 Oct 1855; died on 19 Sep 1934 in Salt Creek, Bath, Kentucky, United States; was buried on 21 Sep 1934 in Alfrey Cemetery, Morehead, Rowan, Kentucky, United States.
2. Henry Clay Alfrey was born on 15 Jan 1864; died on 22 Aug 1936 in Bath County, Kentucky, United States; was buried on 23 Aug 1936 in Alfrey Cemetery, Morehead, Rowan, Kentucky, United States.