Isaac married Cynthia Givens on 14 Oct 1819 in Fleming County, Kentucky, United States. Cynthia (daughter of Mary) was born in 1800 in Kentucky, United States; and died. [Group Sheet] [Family Chart]

1. John A. Darnell was born in 1829 in Kentucky, United States; and died.
2. Amanda Darnell was born in 1832 in Kentucky, United States; and died.
3. Henry A. Darnell was born in 1834 in Kentucky, United States; and died.
4. Penelope Darnell was born in 1839 in Kentucky, United States; and died.
5. William H. Darnell was born on 7 Feb 1841 in Kentucky, United States; died on 21 Nov 1919 in Owingsville, Bath, Kentucky, United States; was buried on 22 Nov 1919 in Bethel, Bath, Kentucky, United States.