James married Catherine McCormick on 24 Jun 1825 in Connersville, Fayette, Indiana, United States. Catherine (daughter of John Wesley McCormick, Sr. and Catherine Anne Drenning Drennan) was born on 20 Dec 1808 in Preble County, Ohio, United States; died on 11 Jun 1900 in Muncie, Delaware, Indiana, United States; was buried in Near Bentonville, Fayette, Indiana, United States. [Group Sheet] [Family Chart]

1. John D. Kirkwood was born on 9 Oct 1826 in Fayette County, Indiana, United States; died on 6 May 1905 in Matthews, Grant, Indiana, United States; was buried on 9 May 1905 in Matthews, Grant, Indiana, United States.
2. James Reed Kirkwood was born on 24 Oct 1828 in Fayette County, Indiana, United States; died on 14 Nov 1903 in Griffin Station, Rush, Indiana, United States; was buried on 15 Nov 1903 in Ben Davis Creek Cemetery, Rush County, Indiana, United States.
3. William Morrison Kirkwood was born on 24 Jun 1830 in Fayette County, Indiana, United States; died on 20 Jan 1914 in Cambridge City, Wayne, Indiana, United States; was buried on 22 Jan 1914 in Riverside Cemetery, Cambridge City, Wayne, Indiana, United States.
4. Thomas Boston Kirkwood was born on 18 Aug 1832 in Indiana, United States; died on 9 Jun 1920 in Indianapolis, Marion, Indiana, United States; was buried on 11 Jun 1920 in Cambridge City, Wayne, Indiana, United States.
5. Mary Jane Kirkwood was born on 21 Jul 1834 in Posey Township, Fayette, Indiana, United States; died on 8 Jun 1853.
6. David Mccormick Kirkwood was born on 12 Nov 1836 in Posey Township, Fayette, Indiana, United States; and died.
7. Joseph L. Kirkwood was born on 22 Dec 1838 in Indiana, United States; died on 27 Nov 1922 in Fairmount, Grant, Indiana, United States; was buried on 29 Nov 1922 in Knox Chapel Cemetery, Point Isabel, Grant, Indiana, United States.
8. Jefferson Kirkwood was born on 23 May 1841 in Posey Township, Fayette, Indiana, United States; died on 7 May 1920 in Cambridge City, Wayne, Indiana, United States; was buried on 9 May 1920 in Riverside Cemetery, Cambridge City, Wayne, Indiana, United States.
9. Elizabeth Ann Kirkwood was born on 3 Mar 1843 in Posey Township, Fayette, Indiana, United States; and died.
10. Margaret Kirkwood was born on 10 May 1845 in Posey Township, Fayette, Indiana, United States; and died.
11. Levingston Alexander Kirkwood was born on 11 Feb 1847 in Posey Township, Fayette, Indiana, United States; and died.
12. Savannah Caroline Kirkwood was born on 25 Dec 1849 in Posey Township, Fayette, Indiana, United States; and died.
13. Amanda Samira Kirkwood was born on 1 Mar 1851 in Posey Township, Fayette, Indiana, United States; and died.
14. Almyra Frances Helen Kirkwood was born on 30 Jan 1854 in Posey Township, Fayette, Indiana, United States; died on 26 Aug 1860 in Posey Township, Fayette, Indiana, United States.

James married Margaret Stewart in 1784 in Ireland. Margaret was born on 15 Mar 1765 in Knocknarney, County Down, Ireland; died on 25 Sep 1835 in Posey Township, Fayette, Indiana, United States; was buried in Bentonville, Fayette, Indiana, United States. [Group Sheet] [Family Chart]